glaucoma annotated bibliography (biology genetics)

biology project and need guidance to help me learn.

hello, I need help with an annotated bibliography that should be based of these :
does glaucoma affect males more than females or females more than males
any topic/question regarding glaucoma
which ethnic group glaucoma affect the most? and why (I like this one better can be any)
research 3 primary articles/sources and 1 review article, which should be at least 4 pages, refer to the https://owl.purdue.edu/ examples/instructions/grade rubric attached
Please only accept if you have the knowledge and skill set to get above a passing grade of 70% and above
If the answers/work you provide me is not above 70% might request a refund and/or only pay you half of the original payment.
will 2XTIP based on how much is completed and the grades received.
some articles I have already found you can use these of find you own:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26258…
https://pubmed.ncbi.nlm.nih.gov/3249334/
Requirements: 4+ pages
BIOL 209 Annotated Bibliography Example 1. APA-style Citation of the article Smith A.J. et al. (2021). A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice. Molecular Psychiatry, 26, 7107 – 7117. https://doi.org/10.1038/s41380-021-01237-4 2. Describe the research question or problem addressed in this paper Previous studies have shown that friendships can have physical and mental benefits including a reduction in mortality and morbidity risks and cognitive declines. Although these benefits are evident, the neurobiological mechanisms underlying them are not. Additionally, long-term friendships are seen in different species allowing for the use of a model organism to study the molecular mechanisms in a controlled experiment. This research uses a model mouse to determine if the genetics of PDE11A is important in establishing friendships. 3. Describe the methods a. What subjects were used Adolescent and adult female and male pde11a knockout mice and BALB/cJ mice were used. C57BL/6 were referenced from prior experiments. b. What experiments were performed The following experiments were used to obtain results: Immunofluorescence of PDE11A4 in brain samples, Western blots of PDE11A4 and actin, social approach/avoidance, social preference assay (mouse psychiatry assay), social odor detection and preference, PDE activity and stereotactic surgeries targeting CA1 of hippocampus. NOTE: This can be detailed or an overview, but make sure you state all subjects (all, genotype, sex and samples, if possible) and all experiments. 4. List a minimum of 3 main findings, conclusions, or main points a. Include the figure/table from results, if necessary  The genetic background of the mice affect the social preference of mouse vs object. C57BL/6 had reduced social approach and BALB/cJ had a change in the social preference.  In adult and adolescent mice, regardless of sex, Pde11a genotype dictates mutual social preference. KO mice rather interact with other KO mice than WT mice.  PDE11A homophily is a driver of mutual social preference, but the exact mechanism is still unknown. NOTE: These statements should come from the results and/or discussion of the paper. Make sure they make sense and are not repetitive. You may have to elaborate briefly. 5. State the relevance of these conclusions to your project I am trying to find the reasons why certain people has lasting friendship and others are short-lived. This study states that there are genetic basis to different similarities in people like alcoholism. Additionally, it shows that the genotype for pde11a can be a contributing factor. This will allow me to potentially identify other molecular mechanisms of friendships. NOTE: Discuss the reason(s) you chose this article and how the contents relate to your project.
BIOL 209 Annotated Bibliography Example 1. APA-style Citation of the article Smith A.J. et al. (2021). A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice. Molecular Psychiatry, 26, 7107 – 7117. https://doi.org/10.1038/s41380-021-01237-4 2. Describe the research question or problem addressed in this paper Previous studies have shown that friendships can have physical and mental benefits including a reduction in mortality and morbidity risks and cognitive declines. Although these benefits are evident, the neurobiological mechanisms underlying them are not. Additionally, long-term friendships are seen in different species allowing for the use of a model organism to study the molecular mechanisms in a controlled experiment. This research uses a model mouse to determine if the genetics of PDE11A is important in establishing friendships. 3. Describe the methods a. What subjects were used Adolescent and adult female and male pde11a knockout mice and BALB/cJ mice were used. C57BL/6 were referenced from prior experiments. b. What experiments were performed The following experiments were used to obtain results: Immunofluorescence of PDE11A4 in brain samples, Western blots of PDE11A4 and actin, social approach/avoidance, social preference assay (mouse psychiatry assay), social odor detection and preference, PDE activity and stereotactic surgeries targeting CA1 of hippocampus. NOTE: This can be detailed or an overview, but make sure you state all subjects (all, genotype, sex and samples, if possible) and all experiments. 4. List a minimum of 3 main findings, conclusions, or main points a. Include the figure/table from results, if necessary  The genetic background of the mice affect the social preference of mouse vs object. C57BL/6 had reduced social approach and BALB/cJ had a change in the social preference.  In adult and adolescent mice, regardless of sex, Pde11a genotype dictates mutual social preference. KO mice rather interact with other KO mice than WT mice.  PDE11A homophily is a driver of mutual social preference, but the exact mechanism is still unknown. NOTE: These statements should come from the results and/or discussion of the paper. Make sure they make sense and are not repetitive. You may have to elaborate briefly. 5. State the relevance of these conclusions to your project I am trying to find the reasons why certain people has lasting friendship and others are short-lived. This study states that there are genetic basis to different similarities in people like alcoholism. Additionally, it shows that the genotype for pde11a can be a contributing factor. This will allow me to potentially identify other molecular mechanisms of friendships. NOTE: Discuss the reason(s) you chose this article and how the contents relate to your project.

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