Cell Biology (2nd part)

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Cell Biology (2nd part)
Regulation of the Cell Cycle
In this article, we will delve into the intricate process of regulating the cell cycle, a crucial concept in cellular biology. It is imperative to comprehend the factors that trigger a cell to progress through interphase and mitosis. Although some cells can withdraw from the cycle and enter G0 phase, certain stimuli or replication activities prompt them to re-enter.
G1/S Checkpoint: One of three checkpoints, special genes continually signal for cellular proliferation. Growth factors are designed to initiate this process by binding with receptors on cells.
Mytogens: Growth factors are also known as mytogens that stimulate mitosis.
It’s important to note that we have not included a diagram due to its potential lengthiness and complexity. Nonetheless, we hope our succinct explanation enhances your understanding of cell cycle regulation.
This receptor couples with Gq protein via G protein-coupling mechanism. Upon binding growth factor triggers dimerization between two such receptors resulting in phosphorylation events on different sites. Mitogens activate tyrosine kinase receptors which then cause phosphorylation at diverse tyrosine residues. A Jonas kinase receptor binds onto specific transcription factors required for triggering response genes inducing proliferation.
Activation of such receptors leads them into stimulating Jhanas kinase enzyme that subsequently facilitates phosphorylation events upon various proteins including transcriptional ones responsible for gene activation necessary during proliferation stages.

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